Teaching biologics design using molecular modeling and simulations (Record no. 174399)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01977nam a22001937a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20241007123918.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240927b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | LDD |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Phillips, Andrew |
| 245 ## - TITLE STATEMENT | |
| Title | Teaching biologics design using molecular modeling and simulations |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | New york:Wiley,2024 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Other physical details | 299-310p. |
| 490 ## - Journal | |
| Volume/sequential designation | 52v,3 |
| Journal | Biochemistry and Molecular Biology Education |
| 500 ## - GENERAL NOTE | |
| General note | Teaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing proper formulations to stabilize mAbs, such as preventing aggregation and mitigating viscosity. Molecular modeling and simulations can improve pharmaceutical products by examining the interactions between mAbs and other compounds, such as excipients. To introduce students to biopharmaceuticals, eight students at the Stevens Institute of Technology participated in a semester-long course to learn the challenges of pharmaceutical development and different computational skills to study biologics design. The students started with a limited background in this field. Throughout one semester, they were introduced to various literature and software tools for modeling antibodies and studying their interactions with excipients. This paper aims to develop a course structure to be replicated at other universities and institutions to teach biopharmaceutical development to students.<br/><br/> |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | biologics,computers in research and teaching,curiculum development,excipients,monoclonal antibodies,protein design |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Srinivas, Anusha and Prentoska, Ilina |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Link text | click here to online access |
| Uniform Resource Identifier | <a href="https://iubmb.onlinelibrary.wiley.com/doi/10.1002/bmb.21813">https://iubmb.onlinelibrary.wiley.com/doi/10.1002/bmb.21813</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Article |
| Suppress in OPAC | No |
| Date last seen | Total checkouts | Price effective from | Koha item type | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Withdrawn status | Home library | Current library | Date acquired |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/27/2024 | 09/27/2024 | Article | Dewey Decimal Classification | Library and Documentation Division NCERT | Library and Documentation Division NCERT | 09/27/2024 |
