Previous research is replete with evidence that emotions and self-regulation work together to influence learning performance, but distinct trait and state features of emotions and self-regulation are rarely considered. With an analytic sample comprising 9,501 daily diaries from 280 adolescents participating in a self-driven learning program, this study used multilevel modeling to examine how trait and state positive and negative emotions and self-regulation interact to predict adolescents' perceived daily learning progress. Results suggested that daily perceived learning progress was associated with trait and state positive emotions and self-regulation, as well as trait negative emotions. Furthermore, there was a significant positive interaction between state positive emotions and state self-regulation on perceived daily learning progress, such that when adolescents' state self-regulation was higher than usual, their perceived daily learning progress was more sensitive to state positive emotion. Results underscore the importance of enhancing adolescents' self-regulation and positive emotion, and the feasibility of facilitating adolescents' learning even if they are in a state of greater negative emotion.