01977nam a22001937a 4500 20241007123918.0 240927b |||||||| |||| 00| 0 eng d LDD Phillips, Andrew Teaching biologics design using molecular modeling and simulations New york:Wiley,2024 299-310p. 52v,3 Biochemistry and Molecular Biology Education Teaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing proper formulations to stabilize mAbs, such as preventing aggregation and mitigating viscosity. Molecular modeling and simulations can improve pharmaceutical products by examining the interactions between mAbs and other compounds, such as excipients. To introduce students to biopharmaceuticals, eight students at the Stevens Institute of Technology participated in a semester-long course to learn the challenges of pharmaceutical development and different computational skills to study biologics design. The students started with a limited background in this field. Throughout one semester, they were introduced to various literature and software tools for modeling antibodies and studying their interactions with excipients. This paper aims to develop a course structure to be replicated at other universities and institutions to teach biopharmaceutical development to students. biologics,computers in research and teaching,curiculum development,excipients,monoclonal antibodies,protein design Srinivas, Anusha and Prentoska, Ilina click here to online access https://iubmb.onlinelibrary.wiley.com/doi/10.1002/bmb.21813 ddc ARTICLES 0 174399 174399 2024-09-27 11:30:10 0 2024-09-27 ARTICLES 0 ddc 0 0 0 LDD LDD 2024-09-27