000			01977nam a22001937a 4500
005			20241007123918.0
008			240927b |||||||| |||| 00| 0 eng d
040			_cLDD
100			_aPhillips, Andrew
245			_aTeaching biologics design using molecular modeling and simulations
260			_aNew york:Wiley,2024
300			_b299-310p.
490			_v52v,3 _aBiochemistry and Molecular Biology Education
500			_aTeaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing proper formulations to stabilize mAbs, such as preventing aggregation and mitigating viscosity. Molecular modeling and simulations can improve pharmaceutical products by examining the interactions between mAbs and other compounds, such as excipients. To introduce students to biopharmaceuticals, eight students at the Stevens Institute of Technology participated in a semester-long course to learn the challenges of pharmaceutical development and different computational skills to study biologics design. The students started with a limited background in this field. Throughout one semester, they were introduced to various literature and software tools for modeling antibodies and studying their interactions with excipients. This paper aims to develop a course structure to be replicated at other universities and institutions to teach biopharmaceutical development to students.
650			_abiologics,computers in research and teaching,curiculum development,excipients,monoclonal antibodies,protein design
700			_aSrinivas, Anusha and Prentoska, Ilina
856			_yclick here to online access _uhttps://iubmb.onlinelibrary.wiley.com/doi/10.1002/bmb.21813
942			_2ddc _cARTICLES _n0
999			_c174399 _d174399